SUMO challenges the current limitations for realistic organ models in a dish by combining stem-cell-based embryo model technology with cutting-edge imaging, genomics, artificial intelligence, and bio-engineering.
SUMO has received funding from the European Union’s Horizon Europe Research and Innovation Programme under grant agreement ID: 101071203 and is part of a portfolio of projects funded under the Engineered Living Materials Pathfinder Challenge by the European Innovation Council and started on November 2022.
Image credits: Igor Meszka
From Embryonic Development to Future Organ Models
The SUMO project develops advanced laboratory models that mimic early human development and organ formation, with the long-term goal of reducing the need for animal testing.
We have made significant progress in developing mouse and human gastruloids, with reproducible early heart and gut development. We are also developing methods to provide these models with blood vessels, enabling them to grow into larger and more complex tissues.
New live-imaging, Raman spectroscopy and AI-based tracking technologies are being developed to monitor and analyse gastruloid development. These tools will support automated optimisation and future applications such as environmental toxicity testing.
Alongside the scientific work, SUMO is developing ethical and regulatory frameworks, engaging with scientists, industry and the public, and translating project technologies towards real-world applications through initiatives such as MicroOrganoTech AS.